Ligands may be coupled to TOYOPEARL AF-Formyl-650M (aldehyde-bearing) resin under mild conditions exclusively using primary amines. The ligand is bound to the resin by a stable secondary amine linkage. A wide variety of industrial enzymes have been immobilized on aldehyde-bearing supports. Typically, these supports have been synthesized by industrial users by partial oxidation of polysaccharide supports (e.g. cellulose and agarose) or partial hydrolysis of polyacetals.

In contrast, TOYOPEARL AF-Formyl-650M resin is a ready-to-use aldehyde support formulated from a dimensionally stable, macroporous matrix. Consistent aldehyde content and physical properties are assured from batch to batch.

Coupling Procedure


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