8.0 nm Monomeric RP Silica Columns
For analysis of small molecules, the 10 nm pore size, 5 micron particle size TSKgel 80Tm and 80Ts columns are offered in 4 different chemistries to suit a variety of needs.
The Type B base silica is of high purity and contains few metal ion impurities. Combined with monomeric bonding chemistry, these reveresed phase columns have an established reputation as general purpose columns for pharmaceutical applications.
The monomeric materials are delineated by the following nomenclature:
- Bonded phase pore size is indicated by the number in the product description, for instance, TSKgel ODS-80Ts has 8.0 nm nominal pore size. The pore size of the base silica is 10 nm.
- T denotes an endcapped phase.
- M, as in TSKgel 80Tm, indicates that a regular endcapping Rx has been performed.
- S, as in TSKgel 80Ts, indicates a more exhaustive endcapping Rx has been performed.
- QA in TSKgel ODS-80Ts QA indicates maximum lot-to-lot reproducibility of retention and selectivity
The TSKgel ODS-80Tm is the general purpose column for drug analysis, basic compounds, and nucleic acid fragments. The TSKgel ODS-80Ts has a complete endcapping that makes it the column of choice for strongly basic compounds and for applications that require operation at pH 7.5.
The TSKgel Octyl-80Ts has faster kinetics than ODS, but lower hydrophobic selectivity, and the TSKgel CN-80Ts serves as an alternative to ODS and Octyl for analysis of polar compounds.